James W. Grimshaw

Defining the role of aerobic respiration in the metabolism and bioenergetics of Enterococcus faecalis

This study investigates the roles of CydAB and Nox in E. faecalis metabolism under aerobic and hypoxic conditions, revealing Nox as the primary oxygen consumer and highlighting the complementary roles of respiratory and oxidative pathways.

Periplasmic SacB as a robust counter-selection tool for genome engineering in the polyploid bacterium Zymomonas mobilis

This paper confirms Zymomonas mobilis is polyploid and introduces a SacB-based counter-selection system for genome engineering.

Transertion provides evidence for coupling of transcription and translation in Bacillus subtilis

The paper shows that in Bacillus subtilis, transcription and translation of a transmembrane protein are coupled, causing the gene to shift from the nucleoid to the plasma membrane.

Conflicts between the DNA replication and repair machineries promote cell death in Gram-positive bacteria

This study shows that inducing excessive DNA replication in Gram-positive bacteria causes cell death, suggesting a potential strategy for antimicrobial development by targeting replication and repair conflicts.

ABCF ATPases involved in protein synthesis, ribosome assembly and antibiotic resistance: structural and functional diversification across the tree of life

The paper analyzes ABCF ATPases across 4505 genomes to uncover their diversity, subfamily relationships, and roles in antibiotic resistance and ribosome function.