Reduced synaptic activity and dysregulated extracellular matrix pathways are common phenotypes in midbrain neurons derived from sporadic and mutation-associated Parkinson's disease patients
Shani Stern, Shong Lau, Andreea Manole, Idan Rosh, Menahem Percia, Ran Ben Ezer, Maxim Nikolaievich Shokhirev, Fan Qiu, Simon T. Schafer, Abed AlFatah Mansour, Tchelet Stern, Pola Ofer, Yam Stern, Ana Mendes Diniz, Lynne Randolph Moore, , Fred H. Gage
The paper compares midbrain neurons from PD patients with mutations and sporadic PD, finding reduced synaptic activity and dysregulated extracellular matrix pathways as common features.
bioRxiv · Dec 31, 2021 · PreprintNeuroscience