Author

Ioana I. N. Da Silva

Salk Institute for Biological StudiesORCID 0000-0002-9486-2319Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Fred H. GageiD· 2 shared Addison J. LanaiD· 1 shared Aidan H. McDonald· 1 shared Ake Tzu-Hui LuiD· 1 shared Anthony S. RicciardulliiD· 1 shared Ariana L. Tucker· 1 shared Baptiste N. JaegeriD· 1 shared Christina K. Lim· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Fred H. GageORCID

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2 papers

Recent·Most cited

CK2 inhibition suppresses glial inflammation in the brain

Ioana I. N. Da Silva, Desiree Ramirez, Sarah Parylak, Leslie A. Wallace, James K. Tucker, Joel M. Erberich, Rutvi Katariya, Aidan H. McDonald, Iryna S. Gallina, Ariana L. Tucker, Jillybeth Burgado, Baptiste N. Jaeger, Jerika J. Barron, Joshua M. Pratt, Monique Pena, , Fred H. Gage

This study identifies CK2 as a key driver of glial inflammation in neurodegenerative disorders and shows that its inhibition reduces inflammation in AD models.

bioRxiv · Aug 5, 2025 · PreprintNeuroscience

Incorporation of a nucleoside analog maps genome repair sites in post-mitotic human neurons

Dylan A. Reid, Patrick Reed, Johannes C. M. Schlachetzki, Ioana I. Nitulescu, Grace Chou, Enoch C. Tsui, Jeffrey R. Jones, Sahaana Chandran, Ake Tzu-Hui Lu, Claire A. McClain, Jean H. Ooi, Tzu‐Wen Wang, Addison J. Lana, Sara B. Linker, Anthony S. Ricciardulli, , Fred H. Gage

The paper identifies DNA repair hotspots in post-mitotic human neurons linked to genes essential for their identity and function.

Science · Apr 1, 2021Peer-reviewedNeuroscience