Sara B. Linker

The paper identifies SLK as a cancer-specific co-regulator of c-Myc using photoproximity labeling, showing it stabilizes c-Myc and drives tumorigenesis through splicing changes.

This study shows that KDM5 demethylases suppress R-loop formation in breast cancer cells, reducing DNA damage and enhancing immune-related gene expression without affecting normal cells.

The paper shows that immature dentate granule cells exhibit reduced transcriptional responses to spatial exploration compared to mature cells.

DeepMosaic detects mosaic single nucleotide variants without control samples using deep convolutional neural networks, achieving high accuracy and uncovering many variants missed by existing methods.

The paper evaluates brain somatic mosaicism in the adult human to identify rules governing cellular distribution during embryogenesis.

The paper compares midbrain neurons from PD patients with mutations and sporadic PD, finding reduced synaptic activity and dysregulated extracellular matrix pathways as common features.

The paper identifies DNA repair hotspots in post-mitotic human neurons linked to genes essential for their identity and function.

The paper introduces a machine learning method to detect somatic L1 insertions in human brain tissue, revealing their widespread distribution in neurons and glia and potential role in neuropsychiatric diseases.

BrainImageR associates gene sets with postmortem brain expression data to identify spatial and temporal associations in human brain development.