Author

Jon D. Goguen

University of Massachusetts Chan Medical SchoolORCID 0000-0002-1372-1697Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexandre DinisiD· 1 shared Athma A. PaiiD· 1 shared Boyao ZhangiD· 1 shared Douglas S. Parker· 1 shared Egil LieniD· 1 shared Jesse W. LehmaniD· 1 shared John BertiniD· 1 shared John M. LeongiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Alexandre DinisORCID

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2 papers

Recent·Most cited

Retrospective analysis of Pseudomonas aeruginosa clinical isolates for secreted PrpL protease: a key virulence factor associated with corneal tissue damage

Douglas S. Parker, Onyedikachi Cecil Azuama, Kashaf Zafar, Jon D. Goguen, John M. Leong, Nikhat Parveen

The paper retrospectively analyzes Pseudomonas aeruginosa clinical isolates to show that corneal isolates have higher PrpL protease activity and pyocyanin production, which contribute to corneal tissue damage.

bioRxiv · Dec 11, 2025 · PreprintMicrobiology

Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance

Boyao Zhang, Pontus Ørning, Jesse W. Lehman, Alexandre Dinis, Leslie Torres-Ulloa, Roland Elling, Michelle A. Kelliher, John Bertin, Megan K. Proulx, Jon D. Goguen, Liv Ryan, Richard K. Kandasamy, Terje Espevik, Athma A. Pai, Katherine A. Fitzgerald, Egil Lien

This study identifies Raver1 as a regulator of Ripk1 RNA splicing, which affects caspase-8-mediated pyroptosis, inflammation, and resistance to Yersinia infection.

Proceedings of the National Academy of Sciences · Feb 13, 2025Peer-reviewedImmunology