Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance
Boyao Zhang, Pontus Ørning, Jesse W. Lehman, Alexandre Dinis, Leslie Torres-Ulloa, Roland Elling, Michelle A. Kelliher, John Bertin, Megan K. Proulx, Jon D. Goguen, Liv Ryan, Richard K. Kandasamy, Terje Espevik, Athma A. Pai, Katherine A. Fitzgerald, Egil Lien
This study identifies Raver1 as a regulator of Ripk1 RNA splicing, which affects caspase-8-mediated pyroptosis, inflammation, and resistance to Yersinia infection.
Proceedings of the National Academy of Sciences · Feb 13, 2025Peer-reviewedImmunology