Sean T. Sweeney

This paper identifies methyl chloride as a breath biomarker for breast cancer linked to cellular metabolism, showing diagnostic accuracy comparable to mammograms.

This study shows chloroform levels increase with age in human, rat, and Drosophila models, suggesting a link to aging and potential for neurodegenerative research.

The paper identifies GEFs and GAPs modulating Rab10 phosphorylation and abundance by LRRK2-G2019S in neurons, showing Crag acts as a GEF and plx as a conventional GAP.

The paper shows that yeast NDI1 restores metabolite levels, ER-mitochondria contacts, and rescues behavioral and lifespan defects in Drosophila with neuronal complex I deficiency.

This study identifies Tmep as essential for proper locomotion in Drosophila by restraining synaptic excitability at the neuromuscular junction.

This study shows JNK signaling enhances antioxidant defenses in neurons, protecting against oxidative stress and synapse damage in both Drosophila and mammalian models.

This study shows reactive oxygen species (ROS) regulate activity-dependent structural plasticity in Drosophila neurons, with DJ-1β modulating synaptic plasticity via the PTEN-PI3K pathway.

This paper characterizes a Drosophila model of saposin deficiency, showing lysosomal storage, neurodegeneration, and calcium homeostasis defects similar to human LSDs.