Jarmo A. Hietala

The paper investigates diurnal and seasonal variations in brain mu-opioid and dopamine D2 receptor signaling in humans using PET data and finds MOR availability increases in the afternoon, with seasonal and trait-anxiety influences.

This study quantifies inter-individual variability in PET-estimated receptor and transporter density across 12 neurotransmitter systems in the human brain.

This study investigates how age, sex, and BMI affect striatal dopamine synthesis capacity in Parkinson's disease patients and healthy controls using PET data.

This study identifies molecular, physiological, and functional mechanisms underlying antipsychotic-related cortical thinning using data from patients with early psychosis and a large meta-analysis.

The paper investigates seasonal variation in D2/3 dopamine receptor availability in the human brain using PET scans and finds a negative correlation between daylength and receptor availability in the striatum.

This study examines D2R availability in neuropsychiatric conditions using PET data from 437 individuals, finding reduced availability in Parkinson's disease and altered interregional connectivity in schizophrenia, depression, and violent behavior.

This study identifies eight genes associated with adult cognitive function through rare coding variants and shows how KDM5B dosage affects cognitive traits in mice and humans.

The paper investigates six rare SLCO1B1 variants in Finnish individuals with psychosis, finding one variant causes loss-of-function and reduced OATP1B1 protein expression.

Neurotransmitter receptor/transporter PET maps (19 targets, 1239 healthy participants) align with connectomes, explain MEG power, and track cognitive gradients and cortical thinning in 13 disorders.

This study examines age and sex differences in striatal D2R availability using a large PET cohort, finding age-related decline and sex differences in D2R levels.

The paper constructs a CYP2D6 copy-number imputation panel and reports pharmacogenetic variant frequencies in Finnish individuals with psychosis, showing high imputation accuracy but limited clinical utility.

This study finds seasonal variation in brain mu-opioid receptor availability in humans, showing an inverted U-shaped relationship with daylength.

The paper investigates the relationship between central CB1-receptor availability and peripheral endocannabinoids in first-episode psychosis patients and healthy controls, finding dysregulated cross-talk between these systems.

This study quantifies interindividual variability and hemispheric lateralization of μ-opioid receptors in the human brain using PET and Bayesian modeling.

Magia automates PET brain data processing, producing outcome measures consistent with manual methods despite anatomical differences in reference regions.