Sirtuin 2 controls global protein synthesis by regulating Rheb-GTPase
Amarjeet Shrama, Yanlin Zi, Anwit Shriniwas Pandit, Kirtika Jha, Vikrant Kumar Sinha, Venkatraman Ravi, Souvik Ghosh, Dimple Nagesh, Bhoomika Shivanaiah, Danish Khan, Arathi Bangalore Prabhashankar, Thoniparambil Sunil Sumi, Sukanya Raghu, Anand Kumar Srivastava, Mahavir Singh, , Nagalingam Ravi Sundaresan
This study identifies SIRT2 as a regulator of global protein synthesis by modulating Rheb-GTPase activity, showing its potential as a therapeutic target for diseases with increased protein synthesis.
bioRxiv · Mar 31, 2025 · PreprintCell Biology