Kirsten Grønbæk

Combining genome-wide polygenic scores with registry data for colorectal cancer risk-based screening

This study evaluates polygenic risk scores (PRS) for colorectal cancer (CRC) screening, showing they stratify risk independently of ancestry and sex but offer limited additional predictive value when combined with FIT.

Bone marrow microenvironment signatures associate with patient survival after guadecitabine and atezolizumab therapy in HMA-resistant MDS

The paper analyzes bone marrow microenvironment changes in HMA-resistant MDS patients treated with guadecitabine and atezolizumab, finding that long-term survivors show reduced immunosuppressive monocytes and expanded effector lymphocytes.

Cholesterol Biosynthesis is a Targetable Vulnerability of CEBPA-mutant Acute Myeloid Leukemia

This study identifies cholesterol biosynthesis as a therapeutic target in CEBPA-mutant AML, showing that statins enhance chemosensitivity in cells with co-mutations in TET2 or WT1.

Mapping the human hematopoietic stem and progenitor cell hierarchy through integrated single-cell proteomics and transcriptomics

The paper integrates single-cell proteomics and transcriptomics to study human hematopoietic stem and progenitor cells, identifying protein markers and dynamics not captured by mRNA alone.