Author

Nanna S. Mikkelsen

Aarhus UniversityORCID 0000-0002-9061-5345Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Rasmus Otkjær BakiD· 3 shared Ana-Maria NitulescuiD· 1 shared Bauke de BoeriD· 1 shared Bo Torben PorseiD· 1 shared Dimitrios L. WagneriD· 1 shared Eric J. AirdiD· 1 shared Erwin M. SchoofiD· 1 shared Grégoire CullotiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

Rasmus Otkjær BakORCID

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Author profile →

3 papers

Recent·Most cited

Cholesterol Biosynthesis is a Targetable Vulnerability of CEBPA-mutant Acute Myeloid Leukemia

Sofie Ulfbeck Schovsbo, Yang Liu, Pedro Aragon-Fernandez, Sandra Leigh Gordon, Mikkel Bruhn Schuster, Jinyu Su, Sachin Pundhir, Nanna S. Mikkelsen, Erwin M. Schoof, Kim Theilgaard‐Mönch, Kirsten Grønbæk, Rasmus Otkjær Bak, Bauke de Boer, Bo Torben Porse

This study identifies cholesterol biosynthesis as a therapeutic target in CEBPA-mutant AML, showing that statins enhance chemosensitivity in cells with co-mutations in TET2 or WT1.

bioRxiv · Feb 20, 2026 · PreprintCancer Biology

Single-stranded HDR templates with truncated Cas12a binding sequences improve knock-in efficiencies in primary human T cells

Ana-Maria Nitulescu, Weijie Du, Viktor Glaser, Jonas Kath, Eric J. Aird, Grégoire Cullot, Robert Greensmith, Nanna S. Mikkelsen, Maik Stein, Rasmus Otkjær Bak, Michael M. Kaminski, Jacob E. Corn, Dimitrios L. Wagner

This study improves CRISPR-Cas12a knock-in efficiency in human T cells by using single-stranded DNA templates with double-stranded Cas-target-sequences, achieving up to 90% knock-in rates for transgene inserts.

Molecular Therapy — Nucleic Acids · May 19, 2025Peer-reviewedImmunology

A truncated reverse transcriptase enhances prime editing by split AAV vectors

Zongliang Gao, Sujan Ravendran, Nanna S. Mikkelsen, Jakob Haldrup, Huiqiang Cai, Xiangning Ding, Søren R. Paludan, Martin Kristian Thomsen, Jacob Giehm Mikkelsen, Rasmus Otkjær Bak

This paper improves prime editing by modifying the reverse transcriptase component to enhance efficiency and enable delivery via split AAV vectors.

Molecular Therapy · Jul 8, 2022Peer-reviewedGenetics