Author

Yonghui Zhao

Washington University in St. LouisORCID 0000-0002-6192-4130Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

John D. TranteriD· 3 shared Rajan SahiD· 3 shared Ashutosh KumariD· 2 shared Daniel J. Lerner· 2 shared Litao XieiD· 2 shared Nihil AbrahamiD· 2 shared Prakash ArullampalamiD· 2 shared Ryan T. MikamiiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCell Biology

John D. TranterORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Endothelial LRRC8C associates with LRRC8A and LRRC8B to regulate vascular reactivity and blood pressure

Qiujun Yu, Yonghui Zhao, Joshua M Maurer, Prakash Arullampalam, Nathaniel John, John D. Tranter, Tarek Mohamed Abd El‐Aziz, Michelle Lin, Daniel J. Lerner, Carmen M. Halabi, Rajan Sah

This study identifies LRRC8C as a non-redundant component of the endothelial LRRC8 complex that regulates vascular reactivity and blood pressure.

Hypertension · Feb 4, 2026Peer-reviewedCell Biology

Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

Ashutosh Kumar, Yonghui Zhao, Litao Xie, Rahul Chadda, John D. Tranter, Ryan T. Mikami, Nihil Abraham, Juan Hong, Ethan Yang Feng, David R. Rawnsley, Haiyan Liu, Kayla M. Henry, Gretchen A. Meyer, Meiqin Hu, Haoxing Xu, , Rajan Sah

This study shows that the lysosomal LRRC8 complex regulates lysosomal pH, morphology, and systemic glucose metabolism by affecting mTOR signaling and autophagic flux.

Science Advances · Sep 26, 2025Peer-reviewedCell Biology

LRRC8 complexes are adenosine nucleotide release channels regulating platelet activation and arterial thrombosis

John D. Tranter, Ryan T. Mikami, Ashutosh Kumar, Gavriel Brown, Tarek Mohamed Abd El‐Aziz, Yonghui Zhao, Prakash Arullampalam, Katrina J. Ashworth, Vishwanath Jha, Nihil Abraham, Chloe Grace Meyer, Abigail Ajanel, Litao Xie, Yongmei Feng, Juan Hong, , Rajan Sah

This study identifies LRRC8 complexes as ATP/ADP release channels in platelets that regulate thrombosis by modulating calcium and PI3K-AKT signaling through P2X1, P2Y1, and P2Y12 receptors.

Blood · Jun 20, 2025Peer-reviewedCell Biology

MrgprA3-expressing pruriceptors drive pruritogen-induced alloknesis through mechanosensitive Piezo2 channel

Ping Lü, Yonghui Zhao, Zili Xie, Huan Zhou, Xinzhong Dong, Gregory F. Wu, Brian Kim, Jing Feng, Hongzhen Hu

The paper identifies TRPV1+/MrgprA3+ prurioceptors and Piezo2 channel signaling as drivers of pruritogen-induced alloknesis.

Cell Reports · Mar 22, 2023Peer-reviewedNeuroscience