The paper uses spatial transcriptomics to analyze cardiomyocyte states in pressure-overloaded mouse hearts, finding pro-fibrotic states linked to microenvironmental changes.

bioRxiv · May 8, 2026 · PreprintGenomics

Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes

Megan Young, Malene Aastrup, Nikayla Patel, Fenn Cullen, Esben Søvsø Szocska Hansen, James E. Clark, Thomas R. Eykyn, Michael Væggemose, Ana Vujić, Loucia Karatzia, Ladislav Valkovič, Jack J. J. J. Miller, Niels Henrik Buus, Christoffer Laustsen, Magdi M. Yaqoob, Dunja Aksentijević

This study shows chronic kidney disease causes systemic metabolic failure across multiple organs, impairing cardiac function and stress resilience by depleting bioenergetic reserves.

Scientific Reports · Nov 21, 2025Peer-reviewedPhysiology

A transient modified mRNA encoding Myc and Cyclin T1 induces cardiac regeneration and improves cardiac function after myocardial injury

Aleksandra Boikova, Gregory A. Quaife-Ryan, Christopher A. P. Batho, Elsa Lawrence, Harley Robinson, Camilla Ascanelli, Karin Jennbacken, Qing‐Dong Wang, Kenny M. Hansson, Adam Seaton, Victoria Rodriguez Noci, Megan J. Bywater, Jasmin Straube, Kamil A. Sokolowski, Brian WC Tse, , Catherine H. Wilson

This study shows that modified mRNA encoding Myc and Cyclin T1 can induce cardiomyocyte proliferation and improve cardiac function after myocardial injury in mice.

bioRxiv · Aug 2, 2023 · PreprintMolecular Biology

Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.

John Lian, Ryan G. Walker, Andrea D’Amico, Ana Vujić, Melanie J. Mills, Kathleen A. Messemer, Kourtney R. Mendello, Jill M. Goldstein, Krystynne A Leacock, Soraya Epp, Emma V. Stimpfl, Thomas B. Thompson, Amy J. Wagers, Richard Theodore Lee

The paper investigates the functional differences between GDF11 and GDF8 by substituting amino acids and identifies distinct effects on skeletal development and muscle.

Life Science Alliance · Jan 11, 2023Peer-reviewedDevelopmental Biology