Carlos Perez Gonzalez

This study shows that frictional forces from cancer-associated fibroblasts induce budding in cancer cell monolayers through a purse-string mechanism, driven by a supracellular contractile ring.

This study shows cancer cells follow intrinsic self-organized programs that coordinate tumor cell state transitions during growth, revealing mechanical gradients and stereotyped patterns of heterogeneity and plasticity.

The paper investigates the mechanical mechanisms of intestinal cell extrusion, showing that it is driven by calcium-triggered myosin 2A mesh dissolution and lamellipodial forces, with extrusion direction determined by these structures.

This study shows PIEZO channels are essential for intestinal stem cell maintenance by sensing mechanical cues from their niche.

The paper shows how mechanical forces from epithelial and mesenchymal compartments coordinate cell shape and fate to form tissue architecture during hair follicle development.