Author
Utrecht UniversityORCID 0000-0001-6174-1134Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Ronja M. Houtekamer, Björn van Sambeek, Karen B. van den Anker…·Martijn Gloerich
This study shows that mechanical strain on intestinal organoids reduces the maturity of absorptive lineage cells by expanding early-stage enterocytes and downregulating maturation programs.
Julian R. Buissant des Amorie, Max A. Betjes, Jochem H. Bernink…·Hugo J.G. Snippert
The paper identifies sequential transcriptomic states of tuft cells along the intestinal crypt-villus axis and shows cytokine-specific differentiation into distinct tuft cell phenotypes.
Marija Matejčić, Meng Wang, Elia Lopez Serrano…·Xavier Trepat
The paper investigates the mechanical mechanisms of intestinal cell extrusion, showing that it is driven by calcium-triggered myosin 2A mesh dissolution and lamellipodial forces, with extrusion direction determined by these structures.
Ronja M. Houtekamer, Mirjam C. van der Net, Marjolein J. Vliem…·Martijn Gloerich
This study shows mechanical strain activates EGFR-ERK signaling in epithelial cells via E-cadherin-induced ADAM17-mediated ligand shedding.
Meryem B. Baghdadi, Ronja M. Houtekamer, Louisiane Perrin…·Tae-Hee Kim
This study shows PIEZO channels are essential for intestinal stem cell maintenance by sensing mechanical cues from their niche.