Kai W. Wucherpfennig

This paper develops LIME, a bacterial platform that engagers T and NK cells to target tumors, showing enhanced cytotoxicity and immune response in preclinical models.

The paper identifies crater-shaped structures in melanoma that enhance immune response to checkpoint blockade therapy in humans and zebrafish.

The paper introduces Sphyder, a tool to detect and rewire phosphorylation motifs, revealing PD-1 signaling mechanisms and enabling synthetic receptor design for immunotherapy.

This study shows MYC overexpression disrupts AR transcriptional pause release, promoting aggressive prostate cancer progression.

The paper uses Perturb-CITE-Seq to identify novel immune evasion mechanisms in cancer by analyzing multi-modal single-cell data from patient-derived models.