Scott Berry

Alternative splicing fine-tunes modular protein interfaces to control protein localisation

This study shows that alternative splicing modulates protein interfaces to control localization by altering exon structure and charge distribution.

Integrating analog and digital modes of gene expression at Arabidopsis FLC

The paper shows that FLC gene expression in Arabidopsis is regulated by both analog and digital modes before cold exposure, with analog preceding digital and leading to gradual repression.

Learning consistent subcellular landmarks to quantify changes in multiplexed protein maps

The paper introduces CAMPA, a deep-learning framework for analyzing subcellular organization changes, and applies it to human cells to study how perturbations affect subnuclear organization and membraneless organelles.

Robust and Versatile Arrayed Libraries for Human Genome-Wide CRISPR Activation, Deletion and Silencing

The paper constructs genome-wide CRISPR libraries for gene ablation, activation, and silencing with high efficacy and reports novel gene regulators and modifiers.

Nuclear RNA concentration coordinates RNA production with cell size in human cells

The paper shows that mammalian cells maintain constant RNA concentrations by adjusting mRNA synthesis and degradation rates in response to changes in cell size.