Coralie L. Guérin

Routine FFPE sections support clinically compatible single-nucleus transcriptomics across six human cancer types

This paper develops a workflow for single-nucleus transcriptomics from FFPE tumor samples, showing reproducible cellular composition analysis across six cancer types.

Nano-flow cytometry of single extracellular vesicles reveals subpopulation differences across cell types and pharmacological perturbations

This study uses nano-flow cytometry to analyze single extracellular vesicles, revealing subpopulation differences across cell types and drug treatments.

The Arp2/3 complex maintains genome integrity and survival of epidermal Langerhans cells

This study shows that the Arp2/3 complex is essential for genome integrity and survival of epidermal Langerhans cells, with Arpc4 deficiency leading to DNA damage and premature aging-like decline.

Tunable DNMT1 degradation reveals cooperation of DNMT1 and DNMT3B in regulating DNA methylation dynamics and genome organization

This study uses tunable DNMT1 degradation to investigate DNA methylation dynamics and genome organization, revealing cooperative roles of DNMT1 and DNMT3B and their impact on heterochromatin and cell fitness.