Author

B. Duygu Özpolat

Marine Biological LaboratoryORCID 0000-0002-1900-965XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:Drosophila· 4 Research Focus:cell type annotation· 2 Research Focus:database / resource· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

Bria M. MetzgeriD· 3 shared Ryan W. NulliD· 3 shared Alexander W. StockingeriD· 2 shared Emily Kuehn· 2 shared Florian RaibleiD· 2 shared Alberto Pérez-PosadaiD· 1 shared Alexandra E. BelyiD· 1 shared Allan M. Carrillo‐BaltodanoiD· 1 shared

Activity by Year

2019-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersDevelopmental Biology

Bria M. MetzgerORCID

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Author profile →

8 papers

Recent·Most cited

Evidence of autonomous neural specification for both brain and ventral nerve cord tissue in Annelida

Nicole B. Webster, Johnny Davila-Sandoval, Allan M. Carrillo‐Baltodano, Skyler Duda, B. Duygu Özpolat, Néva P. Meyer

The paper demonstrates autonomous neural specification for brain and ventral nerve cord in two annelid species, suggesting conservation of this mechanism within Annelida.

bioRxiv · Jan 7, 2026 · PreprintDevelopmental Biology

Sex-biased gene expression precedes sexual dimorphism in the agonadal annelid Platynereis dumerilii

Rannyele Passos Ribeiro, Ryan W. Null, B. Duygu Özpolat

This study identifies sex-biased gene expression and markers for sex identification in Platynereis dumerilii during gametogenesis, revealing conserved and novel genes involved in spermatogenesis and oogenesis.

Development · Mar 11, 2025Peer-reviewedDevelopmental Biology

Molecular profile, source and lineage restriction of stem cells in an annelid regeneration model

Alexander W. Stockinger, Leonie Adelmann, Martin Fahrenberger, Christine Ruta, B. Duygu Özpolat, Nadja Milivojev, Guillaume Balavoine, Florian Raible

The paper maps cellular profiles and lineage restrictions during posterior regeneration in Platynereis dumerilii using single-cell RNA sequencing and mosaic transgenesis, revealing molecular parallels with vertebrate regeneration.

Nature Communications · Nov 18, 2024Peer-reviewedDevelopmental Biology

A genome resource for the marine annelid Platynereis dumerilii

Kevin Nzumbi Mutemi, Oleg Simakov, Leslie Pan, Luca Santangeli, Ryan W. Null, Mette Handberg-Thorsager, Bruno C. Vellutini, Kevin J. Peterson, Bastian Fromm, Tomas Larsson, Emily L. Savage, Mireia Osuna Lopez, Rajna Hercog, Jan Provaznik, Diana Ordoñez‐Rueda, , Detlev Arendt

The paper presents genome assemblies for three Platynereis species to support comparative genomic studies and explore their biology.

bioRxiv · Jun 21, 2024 · PreprintGenomics

Annelid adult cell type diversity and their pluripotent cellular origins

Patricia Álvarez‐Campos, Helena García-Castro, Elena Emili, Alberto Pérez-Posada, Irene del Olmo, Sophie Péron, David A. Salamanca-Díaz, Vincent Mason, Bria M. Metzger, Alexandra E. Bely, Nathan J. Kenny, B. Duygu Özpolat, Jordi Solana

This study identifies and characterizes adult cell types and their pluripotent origins in the annelid Pristina leidyi using single-cell transcriptomics.

Nature Communications · Apr 12, 2024Peer-reviewedGenomics

The cost and payout of age on germline regeneration and sexual maturation in Platynereis dumerilii

Bria M. Metzger, B. Duygu Özpolat

This study examines how age affects germ cell regeneration and sexual maturation in Platynereis dumerilii, finding that older worms regenerate faster and mature earlier despite higher regeneration costs.

bioRxiv · Jan 22, 2024 · PreprintDevelopmental Biology

Segment number threshold determines juvenile onset of germline cluster proliferation in Platynereis dumerilii

Emily Kuehn, David S. Clausen, Ryan W. Null, Bria M. Metzger, Amy D. Willis, B. Duygu Özpolat

The paper investigates how segment number thresholds influence germline cluster proliferation and gametogenesis in juvenile Platynereis dumerilii, finding a correlation between growth state and developmental stages.

Journal of Experimental Zoology Part B Molecular and Developmental Evolution · Nov 18, 2021Peer-reviewedDevelopmental Biology

A scalable culturing system for the marine annelid Platynereis dumerilii.

Emily Kuehn, Alexander W. Stockinger, Jerome Girard, Florian Raible, B. Duygu Özpolat

This paper introduces scalable culturing methods for Platynereis dumerilii to improve experimental control and standardization.

PLoS ONE · Dec 5, 2019Peer-reviewedDevelopmental Biology