Leslie Pan

Multi-modal single-cell profiling reveals transcriptional states and commitment dynamics during sexual reproduction in the diatom Pseudo-nitzschia multistriata

A whole-body cell type atlas mapped into an electron microscopy volume of an annelid worm

The paper maps a whole-body single-cell transcriptome into an electron microscopy volume of an annelid worm to study cellular morphology and gene regulation.

An atlas of shark developing telencephalon reveals ancient origin of basal progenitors and Cajal-Retzius cells

This study uses single-cell and spatial transcriptomics to analyze shark telencephalon development, revealing ancient origins of basal progenitors and Cajal-Retzius cells in gnathostomes.

A genome resource for the marine annelid Platynereis dumerilii

The paper presents genome assemblies for three Platynereis species to support comparative genomic studies and explore their biology.

DNA methylation is linked to the monoallelic expression of MRP3, a diatom mating type determining gene

The paper investigates DNA methylation patterns at the mating type locus MRP3 in diatoms, finding that hypomethylation is necessary but not sufficient for MRP3 expression in sexual cells.

Profiling cellular diversity in sponges informs animal cell type and nervous system evolution

The paper identifies 18 cell types in sponges, including neuroid cells with synaptic gene expression, suggesting early neuro-immune system evolution.