Mette Handberg-Thorsager

Mastodon: the Command Center for Large-Scale Lineage-Tracing Microscopy Datasets

Mastodon is a software platform for analyzing large-scale lineage-tracing microscopy datasets, enabling manual and automated cell tracking and lineage analysis in complex 3D geometries.

Zygotic genome activation is timed by the egg DNA-to-cytoplasm ratio across animals

The paper investigates ZGA timing across 61 animal species and finds that genome size to cytoplasm volume ratio predicts ZGA onset.

Targeting the cell membrane in established and emerging model organisms

The paper develops a toolkit of membrane-localising tags tested across ten animal species to identify effective signals for targeting proteins to the plasma membrane.

A genome resource for the marine annelid Platynereis dumerilii

The paper presents genome assemblies for three Platynereis species to support comparative genomic studies and explore their biology.

From spiral cleavage to bilateral symmetry: The developmental cell lineage of the annelid brain

The paper maps the developmental cell lineage of the annelid brain from zygote to mid-trochophore stage and identifies a subdivision of the larval brain into proliferative and differentiating regions.

Light sheet microscopy for everyone? Experience of building an OpenSPIM to study flatworm development

The paper describes building and using an OpenSPIM microscope to study flatworm development, highlighting its capabilities and challenges in live imaging.