Polina Kosillo

3D-MAESTRO automates processing of large-scale volumetric brain microscopy data, enabling scalable and reproducible analysis of mouse brain structures.

The paper identifies topographic organization in locus coeruleus norepinephrine neurons, linking their morphology, gene expression, and activity to specific brain regions and learning-related behaviors.

This study investigates how mTORC1 and mTORC2 differentially regulate dopamine neuron morphology and function in mice, revealing distinct effects on structure, excitability, and dopamine output.

The paper introduces a DAT-Flp mouse line to selectively label dopaminergic subpopulations using intersectional genetic strategies.

This study shows that loss of Tsc1 in midbrain dopamine neurons leads to structural and functional defects, causing cognitive flexibility deficits that can be mitigated by reducing Raptor.

This paper introduces a non-genetically encoded near-infrared fluorescent nanosensor to image dopamine release in brain tissue with high spatial and temporal resolution.