Ari Adler

A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging

This study creates a multi-omic atlas of brain aging in African turquoise killifish, identifying glucocorticoid signaling activation as a key feature of aging and showing its inhibition can reverse aging phenotypes.

Single-nuclei RNA-sequencing uncovers sexually divergent exercise signatures partially mimicked by TFEB overexpression in mouse skeletal muscle

This study uses single-nucleus RNA-sequencing to compare transcriptional changes in male and female mouse skeletal muscle during exercise and TFEB overexpression, revealing sex-specific metabolic adaptation mechanisms.

Ilastik: a machine learning image analysis platform to interrogate stem cell fate decisions across multiple vertebrate species

The paper introduces Ilastik, a machine learning tool for analyzing stem cell fate decisions in vertebrate species, showing it outperforms manual counting in accuracy and speed.

Widespread sex-dimorphism across single-cell transcriptomes of adult African turquoise killifish tissues

The paper creates a single-cell gene expression atlas of adult African turquoise killifish tissues, revealing widespread sex-dimorphic gene expression, particularly in the liver, and identifies molecular markers for sex identity.

Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish

The paper characterizes gonadal transcriptome changes across lifespan in African turquoise killifish, finding sex-specific declines in piRNA pathways and TE activity in ovaries with aging.