This study analyzes the molecular features of PRAME and BAP1 proteins in melanoma using bioinformatics methods to identify potential therapeutic targets.

Journal of Biomolecular Structure and Dynamics · Mar 14, 2025Peer-reviewedBioinformatics

Unveiling the Genetic Tapestry: Rare Disease Genomics of Spinal Muscular Atrophy and Phenylketonuria Proteins

Debaleena Nawn, Sk. Sarif Hassan, Elrashdy M Moustafa Mohamed Redwan, T. K. Bhattacharya, Pallab Basu, Kenneth H. Lundstrom, Vladimir Nikolaevich Uversky

This study analyzes genetic variations in PAH and SMN1 genes associated with PKU and SMA in Saudi Arabia using quantitative techniques to improve diagnostics and treatments.

International Journal of Biological Macromolecules · Apr 30, 2024Peer-reviewedGenomics

SARS-CoV-2 NSP14 governs mutational instability and assists in making new SARS-CoV-2 variants

Sk. Sarif Hassan, T. K. Bhattacharya, Debaleena Nawn, Ishana Jha, Pallab Basu, Elrashdy M Moustafa Mohamed Redwan, Kenneth H. Lundstrom, Debmalya Barh, Bruno Silva Andrade, Murtaza M. Tambuwala, Alaa A. A. Aljabali, Altijana Hromić‐Jahjefendić, Wagner Baetas‐da‐Cruz, Ángel Serrano‐Aroca, Vladimir Nikolaevich Uversky

This study analyzes NSP14 mutations in SARS-CoV-2 to understand their role in viral evolution and variant diversification.

Computers in Biology and Medicine · Jan 16, 2024Peer-reviewedBioinformatics

Multi-chamber cardioids unravel human heart development and cardiac defects

Clara Schmidt, Alison Deyett, Tobias Ilmer, Simon Haendeler, Aranxa Torres-Caballero, Maria Novatchkova, Michael A. Netzer, Lavinia Ceci Ginistrelli, Estela Mancheño Juncosa, T. K. Bhattacharya, Amra Mujadzic, Lokesh G. Pimpale, Stefan M. Jahnel, Martina Cirigliano, Daniel Reumann, , Sasha Mendjan

This paper develops a multi-chamber cardioid platform to study human heart development and defects by generating compartment-specific gene expression, morphology, and function.

Cell · Nov 28, 2023Peer-reviewedDevelopmental Biology