Structural and Functional Characterization of the KCNJ6 G154C Variant Reveals Severe GIRK2 Channel Gain-of-Function and Opportunities for Drug Repurposing
Michael A. Netzer, Ilya Steshin, Theres Friesacher, Nathan Dascal, Anna Stary‐Weinzinger
The paper characterizes a KCNJ6 G154C variant, revealing its severe gain-of-function in GIRK2 channels and identifies drug candidates for treatment.
bioRxiv · Jul 31, 2026 · PreprintPharmacology & Toxicology