Ronan Le Goffic

Cis-aconitate therapy protects against influenza mortality by dual targeting of viral polymerase and ERK/AKT/NF-κB signaling

This study identifies cis-aconitate as a dual-action antiviral and anti-inflammatory agent that reduces influenza mortality in mice by targeting viral polymerase and ERK/AKT/NF-κB signaling.

A pan-respiratory virus attachment inhibitor with high potency in human airway models and in vivo

This paper develops a broad-spectrum antiviral compound that inhibits multiple respiratory viruses in human airway models and in vivo.

Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters

This study shows SARS-CoV-2 infection causes rapid and severe damage to the olfactory epithelium in golden Syrian hamsters, primarily through infection of sustentacular cells and immune cell infiltration, leading to anosmia.