Marie Galloux

In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA

This study characterizes liquid-liquid phase separation driven by RSV proteins and RNA, identifying key interactions and stoichiometric requirements for condensate formation.

Pre-assembly of biomolecular condensate seeds drives RSV replication

This study shows that RSV forms condensates by pre-assembling replication centers within viral particles, explaining infection heterogeneity and enabling efficient replication without requiring pre-existing condensates.

A single methylation site regulates HRSV nucleocapsid architecture and replication

This study identifies R27 methylation as a regulator of HRSV nucleocapsid structure and replication through molecular dynamics and cryo-EM analyses.

Can Plitidepsin Be Used as an Antiviral Against RSV?

This study investigates plitidepsin's antiviral potential against HRSV, finding it inhibits replication but also causes cellular translation inhibition and eEF1A degradation, suggesting risks for antiviral use.

A pan-respiratory virus attachment inhibitor with high potency in human airway models and in vivo

This paper develops a broad-spectrum antiviral compound that inhibits multiple respiratory viruses in human airway models and in vivo.