Author

Xianfang Wu

Cleveland ClinicORCID 0000-0002-2995-935XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Ana Luisa CostaiD· 1 shared Ann-Kathrin MehnertiD· 1 shared Brandon S. RazookyiD· 1 shared Carl HerrmanniD· 1 shared Carla Siebenkotten· 1 shared Carlos Darío RamíreziD· 1 shared Charles M. RiceiD· 1 shared Charles M. RudiniD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

Ana Luisa CostaORCID

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2 papers

Recent·Most cited

The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistence in hepatocytes

Ann-Kathrin Mehnert, Sebastian Stegmaier, Carlos Darío Ramírez, Vladimir Gonçalves Magalhães, Carla Siebenkotten, Jungen Hu, Ana Luisa Costa, Daniel Kirrmaier, Michael Knop, Xianfang Wu, Thibault Tubiana, Carl Herrmann, Marco Binder, Viet Loan Dao Thi

This study identifies ORF2 as a key HEV protein that suppresses antiviral responses in hepatocytes, enabling viral persistence.

bioRxiv · Feb 3, 2025 · PreprintMicrobiology

TMEM41B is a pan-flavivirus host factor

Hans-Heinrich Hoffmann, William M. Schneider, Kathryn Rozen-Gagnon, Linde A. Miles, Felix Schuster, Brandon S. Razooky, Eliana Jacobson, Xianfang Wu, Soon Yi, Charles M. Rudin, Margaret R. MacDonald, Laura K. McMullan, John Thomas Poirier, Charles M. Rice

The paper identifies TMEM41B as a host factor required for flavivirus infection and shows SNPs in TMEM41B reduce infection in East Asian populations.

Cell · Dec 9, 2020Peer-reviewedMolecular Biology