Fork Reversal Safeguards Epigenetic Inheritance during DNA Replication Under Stress
Qiong Wu, Caixian Zhou, Yue Dou, Nadia I. Martin, Maria Gwit, Tae-Hee Lee, Mark Hedglin, Rosea Chen, Ke Zhu, Tianpeng Zhang, Shangming Tang, Tian Zhang, Tyler Weaver, Wenpeng Liu
This study shows that replication fork reversal is essential for maintaining epigenetic inheritance under replication stress by preventing nucleosome loss and ensuring histone transfer.
bioRxiv · Sep 21, 2025 · PreprintBiochemistry