This study identifies a retroviral origin of vertebrate myelin by showing that RNLTR12-int retrotransposon regulates myelination through SOX10 interaction in multiple vertebrates.

Cell · Feb 1, 2024Peer-reviewedNeuroscience

The neuroprotective effects of Sonic hedgehog pathway agonist SAG in a rat model of neonatal stroke

Vien Nguyen, Manideep Chavali, Amara Larpthaveesarp, Srikirti Kodali, Ginez A. González, Robin J.M. Franklin, David H. Rowitch, Fernando F. Gonzalez

This study shows that a single dose of SAG, a Shh pathway agonist, reduces brain injury and improves cognitive outcomes in a rat model of neonatal stroke.

Pediatric Research · Mar 2, 2021Peer-reviewedNeuroscience

The microbiota regulates inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination

Christopher E McMurran, Alerie Guzman de la Fuente, Rosana G. Peñalva, Ofra Ben Menachem-Zidon, Yvonne Dombrowski, Ginez A. González, Chao Zhao, Fynn N. Krause, Adam M. H. Young, Julian Leether Griffin, Clare A. Jones, Lauren Claire Hollins, Markus M. Heimesaat, Denise C. Fitzgerald, Robin J.M. Franklin

This study shows that microbiota modulates inflammatory responses during CNS demyelination but has little effect on remyelination in mice.

bioRxiv · Mar 13, 2019 · PreprintNeuroscience