Christoph Grunau

The eumetazoan origin of PRDM9 function revealed by cnidarian genome analysis

The study identifies functional PRDM9 orthologs in cnidarians, revealing evolutionary dynamics and suggesting an ancient origin of PRDM9 function.

Not just mutations: Inbreeding depression persists without genetic variation

This study shows inbreeding depression persists even without genetic variation, suggesting epigenetic factors may contribute to its persistence.

The histone code of love: epigenetics of maturation of gonads in the human blood fluke Schistosoma mansoni

This study analyzes histone modifications, chromatin accessibility, and transcription in Schistosoma mansoni gonads to uncover the histone code governing gene expression and reproductive development.

Benchmarking of Chromatin Immunoprecipitation (ChIP-Seq) methods in the Pacific oyster Magallana gigas

This study benchmarks four ChIP-seq methods in the Pacific oyster to identify the most effective for its chromatin structure.

Heterochromatin protein 1 (HP1) of Schistosoma mansoni: non-canonical chromatin landscape and fitness effects

This study investigates the chromatin landscape and fitness effects of SmHP1 in Schistosoma mansoni, finding non-canonical HP1 enrichment and increased parasite fitness upon knock-down.

Chromatin structure around long non-coding RNA (lncRNA) genes in Schistosoma mansoni gonads

The paper examines chromatin modifications around lncRNA genes in Schistosoma mansoni gonads and identifies clusters based on chromatin color similarities and gene region associations.

ENHANCED EFFICIENCY OF RNA-GUIDED CAS12a VERSUS CAS9 TRANSGENE KNOCK-IN AND ACTIVITY AT A SCHISTOSOMA MANSONI GENOME SAFE HARBOR

The paper demonstrates that CRISPR/Cas12a with modified transgenes achieves more efficient gene knock-in in Schistosoma mansoni compared to Cas9.

Targeted insertion and reporter transgene activity at a gene safe harbor of the human blood fluke, Schistosoma mansoni

The paper identifies and characterizes genomic safe harbor sites in Schistosoma mansoni to enable consistent transgene activity through CRISPR/Cas-assisted homology-directed repair.

An epigenetic molluscicide

The paper develops a compound that targets DNA methylation in Biomphalaria glabrata to reduce its fecundity, offering a potential new class of specific molluscicides.

Automated ChIPmentation procedure on limited biological material of the human blood fluke Schistosoma mansoni

The paper demonstrates that automated ChIPmentation can be applied to limited biological material from Schistosoma mansoni, with an operational limit of ≥20,000 cells.

Chromatin landscape dynamics in development of the plant parasitic nematode Meloidogyne incognita

This study investigates histone modifications in the plant-parasitic nematode Meloidogyne incognita to understand their role in development and parasitism, revealing their impact on gene expression and chromatin structure.

DNA methylation during development and regeneration of the annelid Platynereis dumerilii

This study investigates DNA methylation in the annelid Platynereis dumerilii during development and regeneration, showing high levels of 5mC methylation and its role in stem cell function and growth.

Sequencing, de novo assembly and annotation of the genome of the scleractinian coral, Pocillopora acuta

The paper sequences, de novo assembles, and annotates the genome of the coral Pocillopora acuta, demonstrating the technical feasibility and cost-effectiveness of coral genome assembly.

The tropical coral Pocillopora acuta has a mosaic DNA methylome, an unusual chromatin structure and shows histone H3 clipping

This paper describes a method to purify coral chromatin, reports the first methylome of Pocillopora acuta with a mosaic methylation pattern, and identifies an unusual chromatin structure and histone H3 clipping.

Morphological and Genomic Characterisation of the Hybrid Schistosome Infecting Humans In Europe Reveals a Complex Admixture Between Schistosoma haematobium and Schistosoma bovis Parasites.

The paper characterizes a hybrid schistosome in Europe, revealing its genomic composition and compatibility with hosts, and improves the genome assembly of its parental species.

A simple Dot Blot Assay for population scale screening of DNA methylation

The paper validates a dot blot assay for measuring DNA methylation in Biomphalaria glabrata, showing it is cost-effective, requires less DNA, and allows high-throughput screening compared to ELISA.

Notos - a Galaxy tool to analyze CpN observed expected ratios for inferring DNA methylation types

Notos is a Galaxy tool that uses kernel density estimation to analyze CpN observed/expected ratios for inferring DNA methylation types from FASTA files.