Author

Laure Ferry

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Molecular Biology· 5 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:DNA methylation· 5 Research Focus:gene regulatory network inference· 5 Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:human· 4 Approach:statistical model· 4 Organism:mouse· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Pierre‐Antoine DefosseziD· 6 shared Kosuke YamaguchiiD· 4 shared Fumihito MiuraiD· 3 shared Gaël CristofariiD· 3 shared Olivier KirshiD· 3 shared Takashi ItoiD· 3 shared Arpita SarkariD· 2 shared Brianna Rodgers· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMolecular Biology

Pierre‐Antoine DefossezORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

New histone deposition recruits the DNA methylation maintenance machinery at sites of DNA damage repair

Margherita Mori, Sandra Piquet, Léa Girard, Laure Ferry, Kosuke Yamaguchi, Melina Farshchi, Elouan Bethuel, Olivier Kirsh, Magali Hennion, Pierre‐Antoine Defossez, Sophie E. Polo

The paper shows DNA methylation is largely maintained during UV damage repair through recruitment of DNMT1 and DNMT3A, driven by UHRF1 and repair endonucleases, and linked to histone dynamics and transcriptional response.

bioRxiv · Jul 28, 2026 · PreprintMolecular Biology

DNA methylation links lagging strand replication to transposable element control

Nora Fajri, Manon Coulée, Antoine Pigeon, Sugith Babu Badugu, Aylin Seren Güller, Susanne Bandau, Hao Jiang, Angus I. Lamond, Laure Ferry, Max Greenberg, Pierre‐Antoine Defossez, Constance Alabert, Kumar Somyajit, Nataliya Petryk

The paper shows DNA methylation maintenance is linked to lagging-strand replication and TE control in mouse cells, with TE integration preferentially occurring on the lagging strand.

bioRxiv · Jun 23, 2026 · PreprintMolecular Biology

DNA methylation protects cancer cells against senescence

Xiaoying Chen, Kosuke Yamaguchi, Brianna Rodgers, Delphine Goehrig, David Vindrieux, Xavier Lahaye, Matthieu Nolot, Laure Ferry, Sophie Lanciano, Nadine Martin, Pierre R. Dubus, Fumihito Miura, Takashi Ito, Gaël Cristofari, Nicolas Manel, , Pierre‐Antoine Defossez

The paper shows that reduced DNA methylation in cancer cells leads to senescence without DNA damage, involving p21 and cGAS, and demonstrates this in vivo.

Nature Communications · Jul 1, 2025Peer-reviewedMolecular Biology

Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells

Kosuke Yamaguchi, Xiaoying Chen, Brianna Rodgers, Fumihito Miura, Pavel Bashtrykov, Frédéric Bonhomme, Catalina Salinas‐Luypaert, Deis Haxholli, Nicole Gutekunst, Bihter Özdemir Aygenli, Laure Ferry, Olivier Kirsh, Marthe Laisné, Andrea Scelfo, Enes Ugur, , Pierre‐Antoine Defossez

This study shows UHRF1 has non-canonical roles beyond DNMT1 activation in maintaining DNA methylation homeostasis in cancer cells.

Nature Communications · Apr 5, 2024Peer-reviewedMolecular Biology

Comprehensive locus-specific L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites.

Sophie Lanciano, Claude Philippe, Arpita Sarkar, David Pratella, Cécilia Domrane, Aurélien J. Doucet, Dominic van Essen, Simona Saccani, Laure Ferry, Pierre‐Antoine Defossez, Gaël Cristofari

The paper profiles L1 DNA methylation at single-locus resolution across normal and cancer cells, revealing how methylation and transcription interact with L1 integration sites.

Cell Genomics · Feb 1, 2024Peer-reviewedGenomics

A genome-wide knock-out screen for actors of epigenetic silencing reveals new regulators of germline genes and 2-cell like cell state

Nikhil Gupta, Lounis Yakhou, Julien Richard Albert, Anaelle Azogui, Laure Ferry, Olivier Kirsh, Fumihito Miura, Sarah Battault, Kosuke Yamaguchi, Marthe Laisné, Cécilia Domrane, Frédéric Bonhomme, Arpita Sarkar, Marine Delagrange, Bertrand Ducos, , Pierre‐Antoine Defossez

The paper identifies new regulators of germline genes and 2-cell like cell state through a genome-wide CRISPR knock-out screen in mouse ES cells.

Nature Structural & Molecular Biology · Jul 24, 2023Peer-reviewedMolecular Biology

DNA methylation during development and regeneration of the annelid Platynereis dumerilii

Anabelle Planques, Pierre Kerner, Laure Ferry, Christoph Grunau, Eve Gazave, Michel Vervoort

This study investigates DNA methylation in the annelid Platynereis dumerilii during development and regeneration, showing high levels of 5mC methylation and its role in stem cell function and growth.

BMC Biology · Aug 2, 2021Peer-reviewedDevelopmental Biology