Author

Shuangyu Luo

The University of Texas at AustinORCID 0000-0002-2174-1153Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Bradley A. WebbiD· 2 shared Ku‐Lung HsuiD· 2 shared Xiaoding JiangiD· 2 shared Yi‐Chih LiniD· 2 shared 5· 1 shared Arnav PatiliD· 1 shared Congcong Lyu· 1 shared Crystal N. WilsoniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

Bradley A. WebbORCID

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Author profile →

2 papers

Recent·Most cited

A Covalent PFKL Activator Suppresses Tumor Growth

Xiaoding Jiang, Eric M. Lynch, Congcong Lyu, Crystal N. Wilson, Lauren E. Salay, Hayden T. Hess, Scott N. Lyons, Shuangyu Luo, Gibae Kim, Hsin‐Ru Chan, 5, Lauren G. Zacharias, Thomas P. Mathews, Yi‐Chih Lin, Bradley A. Webb, , Ku‐Lung Hsu

This paper develops a covalent PFKL activator that disrupts cancer cell metabolism and delivers a cytotoxic payload, showing efficacy in vitro and in vivo.

Nature Chemical Biology · Aug 5, 2026Peer-reviewedBiochemistry

High-Speed AFM Reveals Ligand-Dependent Supramolecular Switching of Human Phosphofructokinase-1

Yi‐Chih Lin, Shuangyu Luo, Arnav Patil, Nicholas Primanis-Erickson, Xiaoding Jiang, Bradley A. Webb, Ku‐Lung Hsu

This study uses HS-AFM and simulations to show ligand-dependent assembly switching of human PFKL, revealing structural changes in response to ATP and F6P.

bioRxiv · May 12, 2026 · PreprintBiophysics