Tao Lin

Cerebellar Purkinje cell stripe patterns reveal a differential vulnerability and resistance to cell loss during normal aging in mice

The paper shows that Purkinje cell loss in aged mice occurs in parasagittal stripes and is linked to motor dysfunction, with similar patterns observed in human postmortem samples.

The cerebellum contributes to tonic-clonic seizures by altering neuronal activity in the ventral posteromedial nucleus (VPM) of the thalamus

This study identifies the ventral posteromedial nucleus of the thalamus as a source of tonic-clonic seizures, showing cerebellar input drives seizure initiation.

Maturation of Purkinje cell firing properties relies on granule cell neurogenesis

This study shows that granule cell neurogenesis is essential for the maturation of Purkinje cell firing properties and cerebellar-dependent behaviors in postnatal mice.

Deleting Mecp2 from the entire cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice

This study shows that deleting Mecp2 from the entire cerebellum, but not from individual cell types, causes a delay in motor learning in mice.

Purkinje cell neurotransmission patterns cerebellar basket cells into zonal modules that are defined by distinct pinceau sizes

The paper shows that Purkinje cell neurotransmission organizes basket cell pinceaux into distinct size-based zones.

Cerebellar Purkinje cell microcircuits are essential for tremor

This study shows that Purkinje cell activity is essential for tremor, as silencing it blocks tremor in mice and modulating it with deep brain stimulation reduces tremor.

Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells

The paper investigates how inhibitory molecular layer interneurons influence Purkinje cell firing properties in mice by selectively depleting GABAergic neurotransmission from stellate or basket cells.