Jean‐Baptiste Sibarita

Neurospheres from primary rodent brain cells to probe the 3D organization and function of synapses

This paper introduces a 3D neurosphere model from rodent brain cells to study synapse structure and function using advanced imaging and electrophysiology.

Fast volumetric fluorescence lifetime imaging of multicellular systems using single-objective light-sheet microscopy

This paper accelerates fluorescence lifetime imaging (FLIM) using single-objective light-sheet microscopy, achieving faster and less phototoxic imaging of live multicellular systems.

PacL-organized membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis

This study identifies effluxosomes as dynamic membrane structures in M. tuberculosis that coordinate multi-metal resistance through PacL proteins and P-ATPase pumps.

Extracellular matrix deposition controls early differentiation patterns in human cardiac gastruloids

This study shows that extracellular matrix deposition patterns influence early differentiation in human cardiac gastruloids by shaping spatial organization and cell behavior.

SalienceNet: an unsupervised Image-to-Image translation method for nuclei saliency enhancement in microscopy images

SalienceNet enhances nuclei saliency in low-light microscopy images, improving segmentation accuracy by 30% with Otsu thresholding and 26% with StarDist.

Multi-synaptic boutons are a feature of CA1 hippocampal connections that may underlie network synchrony

The paper identifies multi-synaptic boutons (MSBs) in CA1 hippocampal connections, which show reduced variation in synaptic properties and may support network synchrony.

EndophilinA-dependent coupling between activity-dependent calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation

The paper shows how EndophilinA couples calcium influx to synaptic autophagy and identifies a Parkinson-risk mutation that disrupts this process.

Tau forms dynamic hot spots that are resistant to microtubule perturbations and cholesterol depletion

This study identifies dynamic Tau hot spots near the plasma membrane that are stable against microtubule perturbations and cholesterol depletion.

CaMKII activation triggers persistent formation and segregation of postsynaptic liquid phase

The paper shows that CaMKII activation leads to persistent liquid-liquid phase separation with GluN2B, forming stable postsynaptic assemblies that enhance synaptic transmission and memory formation.

SpineJ: A software tool for quantitative analysis of nanoscale spine morphology

SpineJ is a semi-automatic ImageJ plugin designed to quantify nanoscale dendritic spine morphology in super-resolution microscopy images.

Specific nanoscale synaptic reshuffling and control of short-term plasticity following NMDAR- and P2XR-dependent Long-Term Depression

The paper investigates nanoscale synaptic changes during two LTD protocols, showing NMDAR-dependent LTD reorganizes PSD-95 to enhance synaptic facilitation.

Live single molecule microscopy of HIV-1 assembly in host T cells reveals a spatio-temporal effect of the viral genome.

The paper uses live single molecule microscopy to study HIV-1 assembly in T cells, showing the viral genome coordinates the spatio-temporal dynamics of virus formation.