S. Fleur W. Meddens

Rank concordance of polygenic indices: Implications for personalised intervention and gene-environment interplay

The paper evaluates rank concordance between polygenic indices for cardiovascular disease and educational attainment, finding significant variation in rankings and highlighting measurement error's role in discordance.

Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

This study performs a multivariate GWAS on psychiatric disorders and symptoms to identify two genetic liabilities distinguishing common mood disturbances from serious mental illnesses.

Overcoming Attenuation Bias in Regressions using Polygenic Indices: A Comparison of Approaches

This paper compares two methods to reduce measurement error in polygenic indices by simulating and validating their performance on educational attainment and height data.

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

This study identifies genetic loci associated with macronutrient intake and links them to health outcomes using GWAS in over 235,000 individuals.

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

GWAS in over one million individuals identify 611 loci across risk tolerance and risky behaviors, revealing shared genetic architecture and implicating glutamatergic and GABAergic neurotransmission.

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

The paper identifies genetic variants associated with subjective well-being, depressive symptoms, and neuroticism using genome-wide association studies and proxy-phenotype analyses.