Jaime L. Derringer

Simulation of model overfit in variance explained with genetic data

The paper demonstrates that a method for estimating heritability using GWAS and machine learning inflates effect sizes, as shown by simulations with random data.

Imputation of Behavioral Candidate Gene Repeat Polymorphisms in 486,551 Publicly-Available UK Biobank Individuals.

The paper imputes four VNTR polymorphisms and one modifying SNP into 486,551 UK Biobank individuals, enabling rigorous testing of their association with psychiatric phenotypes.

Explaining heritable variance in human character

The paper identifies SNPs that explain a large portion of heritability in personality traits across three samples.

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

This study identifies 4 new risk loci for cannabis use through GWAS, finds genetic overlap with mental health, and shows a causal link between schizophrenia and cannabis use.

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

The paper identifies genetic variants associated with subjective well-being, depressive symptoms, and neuroticism using genome-wide association studies and proxy-phenotype analyses.