Philipp Mertins

The paper models BCR signaling in B cell lymphoma cells to identify conserved network structures and crosstalk mechanisms.

The paper identifies phosphorylation sites in PLPPR3 and shows that phosphorylation at S351 regulates its interaction with BASP1, suggesting a role for the PLPPR3-BASP1 complex in synaptic signaling.

The paper identifies an intracellular hypoglycosylated form of ADA2 absent in DADA2 patients, linking its absence to reduced deaminase activity and variant pathogenicity.

This study identifies phosphorylation of RIF1's intrinsically disordered region as essential for protecting nascent DNA at stalled replication forks during replication stress.

The paper introduces a method to identify zipcodes in neurons, finding two new zipcodes in mouse primary cortical neurons.

This paper maps the C/EBPα interactome using PRISMA and BioID, revealing PTM-dependent interactions and motifs that define its functional plasticity.

This study identifies USP15 as critical for hematopoietic stem cell maintenance and genome integrity, showing its depletion impairs expansion and increases genotoxic stress in leukemia cells.

This study shows that modifying the C-terminal of EAAT2 in a Huntington's disease mouse model reduces hypokinesia symptoms by improving glutamate clearance and reversing some HD-induced changes in EAAT2 interactions.