Author

Jiandong Huo

Centre for Human GeneticsORCID 0000-0002-7899-1815Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:protein structure· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Raymond J. OwensiD· 2 shared Aekkachai TuekprakhoniD· 1 shared Aiste Dijokaite-GuraliuciD· 1 shared Carol V. RobinsoniD· 1 shared Céline Delloye‐BourgeoisiD· 1 shared Chanawee HirunpattarasilpiD· 1 shared Chang LiuiD· 1 shared Claudia PeregrinaiD· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Raymond J. OwensORCID

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Author profile →

3 papers

Recent·Most cited

GPC3-Unc5D complex structure and role in cell migration

Onno Akkermans, Céline Delloye‐Bourgeois, Claudia Peregrina, Maria Carrasquero, Maria C. Kokolaki, Miguel Berbeira-Santana, Mathieu Chavent, Florie Reynaud, Ritu Raj, Jon Agirre, M Aksu, E White, Ed D. Lowe, Dounia Ben Amar, Sofía Zaballa, , Elena Seiradake

This study determines the structure of the GPC3-Unc5D complex and shows its role in guiding neuronal and cancer cell migration.

bioRxiv · Jul 21, 2022 · PreprintNeuroscience

Genome-first detection of emerging resistance to novel therapeutic agents for SARS-CoV-2

Manon Ragonnet‐Cronin, Rungtiwa Nutalai, Jiandong Huo, Aiste Dijokaite-Guraliuc, Raksha Das, Aekkachai Tuekprakhon, Piyada Supasa, Chang Liu, Muneeswaran Selvaraj, Natalie Groves, Hassan B. Hartman, Nicholas A.F. Ellaby, J. Mark Sutton, Mohammad W. Bahar, Daming Zhou, , Sakib Rokadiya

The paper identifies mutations in SARS-CoV-2 variants that confer resistance to monoclonal antibodies by analyzing genomic data and validating their impact on antibody neutralization.

bioRxiv · Jul 14, 2022 · PreprintGenetics

SARS-CoV-2 binding to ACE2 triggers pericyte-mediated angiotensin-evoked cerebral capillary constriction

Chanawee Hirunpattarasilp, Greg James, Felipe Santos Simões de Freitas, Huma Sethi, Josef T. Kittler, Jiandong Huo, Raymond J. Owens, David Attwell

This study shows SARS-CoV-2 binding to ACE2 on pericytes enhances angiotensin II-induced cerebral capillary constriction via AT1 receptors, suggesting AT1 blockers may mitigate brain blood flow reduction in infection.

bioRxiv · Apr 1, 2021 · PreprintNeuroscience