Author

Christina Koupourtidou

Helmholtz MunichORCID 0000-0002-8352-1498Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:clustering· 1

Frequent Co-Authors

Jovica NinkoviciD· 3 shared Frank KirchhoffiD· 2 shared Judith Fischer-SternjakiD· 2 shared Magdalena GötziD· 2 shared Veronika SchwarziD· 2 shared Xianshu BaiiD· 2 shared Alessandro Zambusi· 1 shared Anja SchelleriD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersNeuroscience

Jovica NinkovicORCID

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3 papers

Recent·Most cited

Stab Wound Injury Elicits Transit Amplifying Progenitor-like Phenotype in Parenchymal Astrocytes

Priya Maddhesiya, Finja Berger, Christina Koupourtidou, Alessandro Zambusi, Klara Tereza Novoselc, Judith Fischer-Sternjak, Tatiana Simon, Cora Olpe, Sebastian Jessberger, Magdalena Götz, Jovica Ninkovic

This study identifies injury-induced plastic astrocytes in mice that exhibit self-renewal and neurosphere-forming capabilities, resembling transit-amplifying progenitors in transcriptional profile.

bioRxiv · Sep 10, 2024 · PreprintNeuroscience

Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortex

Christina Koupourtidou, Veronika Schwarz, Hananeh Aliee, Simon Frerich, Judith Fischer-Sternjak, Riccardo Bocchi, Tatiana Simon‐Ebert, Xianshu Bai, Swetlana Sirko, Frank Kirchhoff, Martin Dichgans, Magdalena Götz, Fabian Joachim Theis, Jovica Ninkovic

The paper identifies a shared inflammatory glial cell signature after brain injury using spatial and single-cell transcriptomics in mice, showing common injury-regulated genes across astrocytes, microglia, and oligodendrocyte precursor cells.

Nature Communications · Apr 3, 2024Peer-reviewedNeuroscience

After traumatic brain injury oligodendrocytes regain a plastic phenotype and can become astrocytes

Xianshu Bai, Na Zhao, Christina Koupourtidou, Li‐Pao Fang, Veronika Schwarz, Laura C. Caudal, Renping Zhao, Johannes Hirrlinger, Wolfgang Walz, Shan Bian, Wenhui Huang, Jovica Ninkovic, Frank Kirchhoff, Anja Scheller

This study shows that oligodendrocytes can convert into astrocytes after traumatic brain injury through a transitional AO cell stage, influenced by local environmental cues.

Developmental Cell · May 22, 2023Peer-reviewedNeuroscience