Heather E. Upton

Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs

This study shows that gammaherpesvirus infection leads to tRNA cleavage, producing tRNA fragments that are regulated by tRNA splicing factors and essential for viral replication.

Deep sequencing of yeast and mouse tRNAs and tRNA fragments using OTTR

This study benchmarks the OTTR protocol for characterizing tRNAs and tRNA fragments in yeast and mouse, showing its accuracy and revealing new insights into sperm small RNA content.

Improved precision, sensitivity, and adaptability of Ordered Two-Template Relay cDNA library preparation for RNA sequencing

The paper improves the OTTR method for RNA sequencing by reducing bias and increasing precision in capturing RNA sequences from degraded or processed RNAs.

Streamlined and sensitive mono- and diribosome profiling in yeast and human cells

The paper introduces a streamlined ribosome profiling method using P1 nuclease and Ordered Two-Template Relay, improving sensitivity and reducing bias in yeast and human cells.