Timothy E. Holy

In vivo optical clearing of the mouse brain

This study develops a biocompatible clearing agent for live mouse brain tissue, enabling deeper optical imaging with reduced laser intensity.

The Laminar Organization of a Decision Circuit in Orbitofrontal Cortex is Agnostic to the Variable Encoding Scheme

This study shows that the laminar organization of a decision circuit in the orbitofrontal cortex remains consistent whether decision variables are encoded categorically or mixed.

Laminar Architecture of a Decision Circuit in Orbitofrontal Cortex

This study uses calcium imaging in mice to show that different layers of the orbitofrontal cortex encode decision variables differently, revealing a layered architecture for economic decision-making.

The Representation of Decision Variables in Orbitofrontal Cortex is Longitudinally Stable

This study shows that neural representations of decision variables in the orbitofrontal cortex of mice remain stable over 20 weeks, with only modest representational drift.

STARDUST: a pipeline for the unbiased analysis of astrocyte regional calcium dynamics

STARDUST is a pipeline that analyzes astrocyte calcium dynamics by detecting and extracting discrete calcium signals from fluorescence recordings.

Polyphasic circadian neural circuits drive differential activities in multiple downstream rhythmic centers

The paper identifies three distinct circadian phases in Drosophila pacemaker networks and shows how they drive rhythmic activity in downstream neurons.

Circadian pacemaker neurons display co-phasic rhythms in basal calcium level and in fast calcium fluctuations

The paper shows that circadian pacemaker neurons in Drosophila exhibit co-phasic rhythms in basal calcium levels and fast calcium fluctuations, driven by IP3R and T-type channels respectively.

Central vestibular tuning arises from patterned convergence of otolith afferents

This study demonstrates that convergence of otolith afferents with similar or differing preferred directions shapes the tuning complexity of central vestibular neurons in zebrafish.

Neural Mechanisms of Economic Choices in Mice

This study investigates economic choice mechanisms in mice, showing that the lateral orbital area is critical for decision-making, with neuronal representations similar to primates but spatially encoded.

A molecular logic of sensory coding revealed by optical tagging of physiologically-defined neuronal types

This study introduces PhOTseq, a method to identify molecular markers for functionally defined neuronal types, and applies it to uncover receptor-ligand pairings in vomeronasal neurons.

Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay

The paper identifies a circadian pathway in Drosophila where morning and evening oscillators drive pre-motor centers via specific dopaminergic neurons, resulting in a two-peak locomotor activity pattern.