Merissa Olmer

This study profiles human cartilage across OA grades, revealing changes in fibronectin expression, splicing, and receptor signaling during disease progression.

The paper uses single-nucleus multiome sequencing to analyze subchondral bone in OA, finding increased osteocyte SMAD2/3 activity and chondrocyte-derived FN1 signaling with disease severity.

This study identifies 3'tRNAAsp(GTC)-derived fragment as a regulator linking inflammation to translational reprogramming in chondrocytes during osteoarthritis.

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

This study identifies sensory fiber types in mouse TMJ tissues using immunohistochemistry, finding peptidergic fibers dominate with minimal non-peptidergic nociceptors.

The paper introduces vSPACE, a method to create virtual spatial representations of single-cell RNA sequencing data from human articular cartilage, revealing consistent zonal patterns across donors.