Martin Lotz

Integrated transcriptomic and epigenomic profiling of human cartilage reveals coordinated changes in fibronectin expression, splicing, and receptor signaling during osteoarthritis progression

This study profiles human cartilage across OA grades, revealing changes in fibronectin expression, splicing, and receptor signaling during disease progression.

Single-nucleus multiome profiling reveals osteocyte-centered remodeling of human subchondral bone across osteoarthritis severity

The paper uses single-nucleus multiome sequencing to analyze subchondral bone in OA, finding increased osteocyte SMAD2/3 activity and chondrocyte-derived FN1 signaling with disease severity.

DRG meningeal tertiary lymphoid structures are regulated by B cells as a pronociceptive locus after peripheral nerve injury

The paper shows that B cell-derived IgG in DRG meninges forms tertiary lymphoid structures (TLSs) that drive neuropathic pain after peripheral nerve injury, and disrupting TLSs prevents pain.

Extracellular Sulfatase Regulation of BMP-7 and FGF-2 Signaling in Human Articular Chondrocytes

The paper confirms that Sulf-1 and Sulf-2 regulate BMP-7 and FGF-2 signaling in human articular chondrocytes by affecting Smad1/5 and Erk1/2 phosphorylation.

Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritis

The paper identifies four synovial transcriptional clusters in knee OA linked to cartilage degeneration severity through bulk and single-cell RNA-seq analyses.

3'tRNAAsp(GTC)-derived fragment links inflammation to post-transcriptional reprogramming in chondrocytes during osteoarthritis.

This study identifies 3'tRNAAsp(GTC)-derived fragment as a regulator linking inflammation to translational reprogramming in chondrocytes during osteoarthritis.

A standardized, open-source, portable model for noninvasive joint injury in mice

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

Identification of Sensory Fiber Types in Mouse Temporomandibular Joint Tissues

This study identifies sensory fiber types in mouse TMJ tissues using immunohistochemistry, finding peptidergic fibers dominate with minimal non-peptidergic nociceptors.

vSPACE: Exploring Virtual Spatial Representation of Articular Chondrocytes at the Single-Cell Level

The paper introduces vSPACE, a method to create virtual spatial representations of single-cell RNA sequencing data from human articular cartilage, revealing consistent zonal patterns across donors.