India M Baker

BCOR mutations establish a persistent culture-adaptive state in human induced pluripotent stem cells

This study identifies BCOR mutations in hiPSCs as a culture-adaptive state causing chromatin, transcriptomic, and proteomic changes, and develops a qPCR assay for detection.

The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

This study identifies CHD4's role in restricting transcription factor binding to maintain regulatory function and silence cryptic enhancers.

Rapid degradation of 6 class I HDAC complexes reveals minimal functional overlap between complexes

This study identifies primary targets of individual class I HDAC complexes and shows that their rapid degradation leads to gene regulation with significant specificity and antagonistic effects.

Rapid degradation of Histone Deacetylase 1 (HDAC1) reveals essential roles in both gene repression and active transcription

This study rapidly degrades HDAC1 in ESCs to show its dual role in gene repression and active transcription by modulating histone acetylation at promoters and enhancers.