Cell BiologyBloodPeer-reviewed
LRRC8 complexes are adenosine nucleotide release channels regulating platelet activation and arterial thrombosis
John D. Tranter, Ryan T. Mikami, Ashutosh Kumar…·Rajan Sah
This study identifies LRRC8 complexes as ATP/ADP release channels in platelets that regulate thrombosis by modulating calcium and PI3K-AKT signaling through P2X1, P2Y1, and P2Y12 receptors.
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