LRRC8 complexes are adenosine nucleotide release channels regulating platelet activation and arterial thrombosis
John D. Tranter, Ryan T. Mikami, Ashutosh Kumar, Gavriel Brown, Tarek Mohamed Abd El‐Aziz, Yonghui Zhao, Prakash Arullampalam, Katrina J. Ashworth, Vishwanath Jha, Nihil Abraham, Chloe Grace Meyer, Abigail Ajanel, Litao Xie, Yongmei Feng, Juan Hong, , Rajan Sah
This study identifies LRRC8 complexes as ATP/ADP release channels in platelets that regulate thrombosis by modulating calcium and PI3K-AKT signaling through P2X1, P2Y1, and P2Y12 receptors.
Blood · Jun 20, 2025Peer-reviewedCell Biology