Caroline Demangel

This study targets the Sec61 translocon to suppress pathogenic light-chain production in AL amyloidosis, showing that mycolactone and synthetic inhibitors like A317 reduce LC secretion while highlighting the need for client selectivity.

The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

This paper introduces a high-throughput and ultrasensitive immunopeptidomics platform that identifies thousands of MHC I and II peptides from low-input samples.

The paper shows that lipid droplets store polyunsaturated fatty acids (PUFAs) that are critical for bacterial clearance and inflammation by macrophages.

The paper identifies novel genetic and non-genetic factors associated with plasma protein levels in healthy donors, highlighting their impact on immune response variability.

This study shows that gut microbiota changes induced by chronic stress affect depressive-like behaviors and adult hippocampal neurogenesis through the endocannabinoid system in mice.