This study uses a Rosella-PLIN2 biosensor to track lipophagy in atherosclerosis, revealing cell-specific differences in lipid metabolism and immunometabolic interactions.

Autophagy · May 21, 2026Peer-reviewedCell Biology

Postoperative Stress Accelerates Atherosclerosis through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Dominique M. Boucher, Victoria Lorant, Valérie Rochon, Abigail Carter, Cameron Stotts, My-Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David P. Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet

This study shows that postoperative stress impairs reverse cholesterol transport and accelerates atherosclerosis through inflammatory remodeling of HDL and foam cell apoptosis.

Advanced Science · Jan 30, 2026Peer-reviewedBiochemistry

The impact of gut microbiota on depressive-like behaviors and adult hippocampal neurogenesis requires the endocannabinoid system

Grégoire Chevalier, Eleni Siopi, Laure Guenin‐Macé, Maud Pascal, Thomas Laval, Aline Rifflet, Ivo Gomperts Boneca, Caroline Demangel, François Leulier, Gabriel Lepousez, Gérard Eberl, Pierre‐Marie Lledo

This study shows that gut microbiota changes induced by chronic stress affect depressive-like behaviors and adult hippocampal neurogenesis through the endocannabinoid system in mice.

bioRxiv · Jul 29, 2019 · PreprintNeuroscience