Zhenglin Guo

Rare coding variation implicates thirteen genes in bipolar disorder across 232,536 individuals from global populations

Disrupted Sleep-Dependent Neural Oscillations and Transcriptomic Changes in the Cacna1g Loss-of-Function Mouse Model Implicated in Schizophrenia

Loss of CACNA1G disrupts sleep rhythms and gene regulation, creating a mismatch between brain state and behavior linked to schizophrenia.

A spectrum of altered non-rapid eye movement sleep in schizophrenia

This study replicates group-level sleep EEG differences in schizophrenia and shows increased patient-to-patient variability in NREM metrics, with medication and age-related effects contributing to this heterogeneity.

Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases

This paper introduces SuSiEx, a cross-population fine-mapping method that improves resolution and power by integrating data across ancestries, leading to more accurate identification of causal variants in complex traits and diseases.

Bias in group-level EEG microstate analysis

This study identifies biases in group-level EEG microstate analysis and proposes a paired analysis approach to reduce errors from subgroup topography differences.

Improving Polygenic Prediction in Ancestrally Diverse Populations

This paper introduces PRS-CSx, a method that improves polygenic prediction across ancestrally diverse populations by integrating GWAS summary statistics and sharing genetic effects.

Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

This study identifies NREM sleep and wake EEG biomarkers associated with schizophrenia symptom severity and disease status.